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Quality, precision, and efficiency are vital for ensuring the success of any fertility treatment. Conventional sperm preparation techniques, such as centrifugation using a density gradient, are not only laborious and challenging, but they additionally contribute to the fragmentation of sperm DNA and cellular stress, reducing the chances of success.
ZyMot sperm separating devices are an innovative, effective, natural, and simple approach for isolating the healthiest sperm for in-vitro fertilisation (IVF), intra-uterine insemination (IUI), and intracytoplasmic sperm injection (ICSI) procedures with the lowest DNA fragmentation. This page discusses all about the ZyMot fertility device.
What is ZyMot?
ZyMot is a sperm separator device, often known as a chip, that is used in IVF laboratories to prepare and choose sperm for IVF, ICSI, or IUI. ZyMot utilises a membrane filter within the chip that lets only the most motile sperm to pass through.
This technique is designed to replicate the features of normal conception by picking sperm based on how well they can swim actively while avoiding centrifugation, which can occasionally damage sperm membranes.
History and Development of ZyMot
ZyMot is an important advancement in the field of fertility treatments. The device has been developed in response to the need for better sperm selection methods that could address the problems associated with conventional sperm processing techniques, such as centrifugation, which can cause damage to sperm membranes. The ZyMot device uses a specialised microporous membrane that permits only the most healthy and most motile sperm to pass through, hence enhancing the quality of sperm chosen for fertilisation procedures.
How Does Zymot Work?
ZyMot works on the concept of microfluidics, in which sperm is put into the device inlet and is allowed to pass through a filter. The process involves the following:
- Embryologists inject semen into the Zymot device's inlet port.
- The most motile and healthy sperm swim through the internal membrane filter before being collected and used for treatment. The lower quality sperms are left behind because they are unable to pass through the membrane barrier.
- The chosen, high-quality sperm is then collected for use in IVF or ICSI procedures.
Unlike conventional methods, processing a sample of semen using the Zymot device requires no centrifugation, which is believed to be one of the main reasons for DNA fragmentation in compromised sperm samples.
Benefits of Using ZyMot for IVF
Following are some of the benefits of using ZyMot:
- ZyMot effectively isolates the most motile and healthy sperm, resulting in higher-quality embryos and higher pregnancy rates.
- ZyMot does not use centrifugation and the process is gentle and similar to the process of natural selection in the female reproductive tract.
- Research studies have found that ZyMot can increase clinical pregnancy rates, especially in individuals with male infertility.
- ZyMot devices require about 80% less hands-on technical time, resulting in less potential for human error.
- Little preparation is required, and sperm separation can be standardised in clinical settings to reduce variation among lab professionals.
Who Should Consider Zymot?
Zymot technology is a good choice for many individuals who need fertility treatment in order to have children. This approach may be especially effective for males who have low sperm quality and previously had substantial quantities of fragmented DNA in their sperm, as well as couples who have had previous unsuccessful IVF cycles.
Is ZyMot Effective?
ZyMot is a relatively new technology,. The recent scientific literature on ZyMot concluded the following:
- ZyMot resulted in considerably lower numbers of sperm than usual preparation methods.
- Sperm prepared with ZyMot performed much better than conventional procedures in terms of overall motility, proper sperm morphology (shape), and fragmentation of sperm DNA levels.
- There was no difference in the methods used for progressive motility.
- ZyMot collected the most healthy sperm with the least DNA fragmentation when compared to regularly used sperm preparation procedures.
- Finally, ZyMot sperm separation for ICSI increased the likelihood of a clinical pregnancy compared to traditional sperm preparation methods.
Clinical Applications of ZyMot
ZyMot is usually performed alongside ICSI, which involves injecting a single sperm directly into an egg. This approach is particularly useful for individuals having low numbers of sperm or impaired motility of sperm. The technology can also be used in intrauterine insemination (IUI) procedures, further increasing its clinical relevance in fertility treatments.
Zymot in Your IVF Journey
Integrating ZyMot into your IVF journey can be life-changing, particularly if male infertility is a problem. The treatment is simple and can be effortlessly incorporated into regular IVF or IUI treatments. After obtaining a sperm sample, the sperm is processed using the ZyMot technology to identify the healthiest ones. These chosen sperm are subsequently used for fertilisation, either through traditional IVF or ICSI.
Frequently Asked Questions
What is ZyMot? What exactly does it do?
The Zymot device is an alternative technique for preparing sperm samples that avoids the centrifugation step used in the conventional washing method.
*To use the Zymot, the sample must contain motile sperm.
For whom is ZYMOT suggested?
Patients who have been diagnosed with:
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Compromised sperm quality as a result of DNA fragmentation
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Recurrent miscarriages
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Implantation failures
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Poor embryo quality
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Failed assisted reproduction treatments
